Nature has been the greatest experimenter on Earth for millennia.

Nature has been the greatest experimenter on Earth for millennia. New mutations continuously arise in our genomes and their fate is determined by the action of purifying selection, genetic drift, and positive selection. Comparative sequence analysis at individual, population, and species levels yields a record of their outcomes in form of patterns of conservation and divergence of genomes. These evolutionary patterns and their underlying causes are now the foundation of many approaches to forecast adaptive and disruptive mutations found in our personal and somatic genomes. Predictive evolutionary techniques and the associated fundamental research investigations are encompassed by Phylomedicine, which is becoming a key discipline at the intersection of molecular evolution, genomics, and biomedicine. I will present highlights of our recent research in phylomedicine of Mendelian, cancer, and complex diseases.